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The precise mechanism by which hydroxyurea produces its antineoplastic effects cannotat presentbe describedHoweverthe reports of various studies in tissue culture in rats and humans lend support to the hypothesis that hydroxyurea causes an immediate inhibition of DNA synthesis by acting as a ribonucleotide reductase inhibitorwithout interfering with the synthesis of ribonucleic acid or of proteinThis hypothesis explains whyunder certain conditionshydroxyurea may induce teratogenic effects.

It is important to make sure you are taking the correct amount of medication every timeBefore every dosecheck that what you are taking matches what you have been prescribed.

Elderly patients may be more sensitive to the effects of hydroxyureaand may require a lower dose regimenHydroxyurea is excreted by the kidneyand the risk of adverse cheap himcocid himalaya reactions to this drug may be greater in patients with impaired renal functionBecause elderly patients are more likely to have decreased renal functioncare should be taken in dose selectionand it may be useful to monitor renal functionsee DOSAGE AND ADMINISTRATION

Hydroxyurea may increase blood uric acid concentrationAlthough no specific dose adjustments are necessary with probenecid or sulfinpyrazoneAnturanehydroxyurea should be used cautiously with uricosuric medications.

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