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Factors that may increase the risk of lactic acidosissee section 4.4should be reviewed before considering initiation of metformin.

Metformin is indicated in the treatment of type 2 diabetes mellitus not satisfactorily controlled by dietwhere the risk of lactic acidosis is minimised by excluding predisposing factorsespecially impaired renalhepatic or cardiovascular functionMetformin may be used as initial therapy or in sulphonylurea furosemide lasix no prescription failureeither alone or in combination with a sulphonylurea or as adjuvant therapy in insulin-dependent diabetes.

Controlled clinical studies of metformin did not include sufficient numbers Order cytoxan infusion of elderly patients to determine whether they respond differently from younger patients.

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